Sr Staff Program Manager, MES Custom Software Development Transformation

The job

LIVE Employer public job feed (private-sector employer) Source: the employer's public careers feed · Data: listed 2026-10-15

Job description

Sr Staff Program Manager, MES Custom Software Development Transformation                                                            (Hybrid in South San Francisco, CA or Wilsonville, OR)

Summary

Twist Bioscience is embarking on a strategic transformation of its Manufacturing Execution System (MES) to modernize our technology platform, enable operational scalability, and support the evolving needs of our business. We are seeking an experienced Sr Staff Program Manager to drive the strategic planning, cross-functional coordination, and hands-on execution of this business-critical initiative.  Reporting directly to the Sr Director of Technology Operations, this role will lead the delivery of the MES replatform efforts, bringing structure, Agile delivery discipline, and strong program governance to ensure successful execution. Partnering closely with Technology, Manufacturing Operations, R&D, Quality, and business stakeholders, this individual will be responsible for aligning priorities, managing complex dependencies, and driving decisions.

Key Responsibilities

• Strategic Program Leadership: Lead the overall MES replatform transformation, translating strategic objective into an actionable, integrated program roadmap.
• MES Project Execution: Lead day-to-day execution of the MES replatform, managing timelines, scope, resources, and deliverable milestones.
• Stakeholder Engagement: Partner closely with business users, IT process owners, and external software vendors/agencies to communicate status, align expectations, and resolve cross-functional issues.
• Budget & Resource Management: Track project expenditures, support financial budgeting, and ensure efficient resource allocation across core initiative tracks.
• Process & Change Optimization: Implement company and departmental procedures that affect immediate operations. Assist with organizational change management to ensure smooth system adoption and transition from legacy platforms.
• Risk & Quality Management: Proactively identify technical, operational, and integration risks. Enforce quality-control practices, compliance standards, and validation protocols required in manufacturing software environments.

Qualifications

• Education: Bachelor’s degree in Computer Science, Software Engineering, Industrial Engineering, Information Technology, or a related field. 
• Overall experience: Minimum of 12 years of experience performing and improving business processes, with a strong focus on manufacturing, life sciences, engineering, or operations.
• Agile & Delivery Expertise: Proven expertise in Agile project delivery frameworks (Scrum Master, SAFe, or PMI-ACP certifications preferred) with a strong track record of facilitating Agile ceremonies and managing iteration cycles.
• Project Leadership: 5 plus years in project or program management leading cross-functional custom software development teams.
• Solid hands-on understanding of the custom software development lifecycle (SDLC), modern software architecture principles, and business transformation frameworks. Biotech or pharmaceutical industry experience is preferred.
• Strong leadership, negotiation, and conflict-resolution skills, with a track record of translating complex manufacturing requirements into actionable software solutions. 

Preferred Qualifications

• Certifications: Certified ScrumMaster (CSM), PMI-ACP, or SAFe Agilist.
• Industry Focus: Specialized experience in biotech, pharmaceutical, semiconductor, or advanced discrete manufacturing environments.
• Domain Knowledge: Deep understanding of custom software development lifecycles (SDLC), shop-floor manufacturing processes, SCADA/PLC integration, and ISA-95 standards.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

Explore around this job

Field: Technology Sub-niche: Software engineering All jobs at Twist Bioscience Jobs in California Jobs in USA - South San Francisco, CA California state guide

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About the role

This is a — role in the Technology field (Software engineering) at Twist Bioscience.

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The city

USA - South San Francisco, CA is not one of the cities with its own page in our guides, so here is the state: California.

The state economy in brief

California is in the West region (Pacific division) and has 39,287,376 residents (the 1st largest of the 50 states and DC by population), with a median age of 37.9. Its economy produced about $4,438,822 million in the latest four quarters (BEA), 1st among states and DC, equal to $112,983 per resident.

Jobs and the labour market

The unemployment rate was 5.1% in 2026M09, which is 49th lowest of 51 (1st is the lowest). Employers had job openings equal to 3.6% of employment, 37th highest of 51, a measure of how hard it is to hire. The median wage across all occupations is $58,240 a year ($28.00 an hour), 14% above the national median ($58,240 against $50,980).

What people do and what it pays

The occupations with the most jobs in California are Home Health and Personal Care Aides (970,150 jobs, median $34,320); Fast Food and Counter Workers (449,840 jobs, median $42,280); Retail Salespersons (376,460 jobs, median $38,440); Laborers and Freight, Stock, and Material Movers, Hand (355,500 jobs, median $44,710); Registered Nurses (338,940 jobs, median $140,270). Among occupations with at least 2,000 jobs, the best paid are Airline Pilots, Copilots, and Flight Engineers (median $353,900); Psychiatrists (median $353,500); General Internal Medicine Physicians (median $313,890). Compared with the nation, the state is most specialised in farming, fishing, and forestry (4.1 times the national share of workers) and healthcare support (1.5 times the national share of workers).

Cost of living, taxes and workplace rules

Prices are above the national average in California: the regional price parity is 110.7 against 100 for the whole country (51st lowest of 51). Median gross rent is $2,036 a month and the median household income $99,122, so a year of rent equals 24.6% of income; the median home value is $734,700. The state minimum wage is $16.90 (the higher of state and federal rates applies to most workers). State income tax on wages: Graduated, top rate 13.30%. It is not a right-to-work state, so union contracts can require fees from covered workers. It runs a state paid family and medical leave programme.

People and commuting

27.0% of residents were born abroad and 37.1% of adults hold a bachelor's degree or higher. Among workers, 65.7% drive alone, 2.9% use public transit and 17.2% work from home; 19.4% commute 45 minutes or more.

State guide: California →

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Career paths

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Cybersecurity (762) Data, analytics and AI (3719) Cloud, IT and infrastructure (1147) Product management (927)

Distances

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The employer

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Same sub-niche: Software engineering

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FAQ

What is the Sr Staff Program Manager, MES Custom Software Development Transformation job at Twist Bioscience?

A private-sector role in technology (software engineering) listed 26 days ago. The full description is on this page and on the employer's page.

Where is this job?

USA - South San Francisco, CA.

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How much does it pay?

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What is the cost of living there?

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How old is this listing?

It was posted on 2026-10-15 (26 days ago). Jobs older than 90 days are not shown.

Are there similar jobs?

Yes: browse software engineering jobs in California.

Sources and terms

• Job data: Twist Bioscience careers page public feed (listing dated 2026-10-15). The job disappears from this site when it disappears from the source.
• Wages and projections: BLS OEWS (May 2025) and Employment Projections 2025–35.
• City and county figures: Census Bureau ACS 2020–2024, BEA, BLS QCEW and LAUS, NASA POWER climatology; distances from Census Gazetteer coordinates.

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Sources

• BLS OEWS (wages and employment by occupation, May 2025)
• BLS Employment Projections 2025–35
• BLS Local Area Unemployment Statistics
• BLS JOLTS
• BLS State and Metro Area Employment
• Census Bureau American Community Survey (via Census Reporter)
• BEA GDP by state and Regional Price Parities
• IRS 2026 tax adjustments
• U.S. Department of Labor, minimum wage by state
• Tax Foundation state income tax rates 2026
• USAJOBS
• USCIS
• U.S. Department of State, visas
• NASA POWER climatology
• GeoNames / Census Gazetteer (coordinates)