Jobs Private USA → Technology → Software engineering → Staff Software Engineer, Variant Classification

Staff Software Engineer, Variant Classification

Labcorp · San Francisco, CA · posted 6 days ago

In short: Staff Software Engineer, Variant Classification at Labcorp in San Francisco, CA, posted 6 days ago.

By AtiveSite · Published 07/11/2026 · Updated 09/11/2026 · Every figure is linked to its source below.

Labcorpemployer

San Francisco, CAlocation

Software engineeringsub-niche

6 days agoposted

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The job

LIVE Live feed (private-sector employer) Source: The Muse public API · Data: listed 2026-11-03

Employer	Labcorp
Location	San Francisco, California
Field	Technology › Software engineering
Level	Mid Level
Source category	Software Engineering
Posted	2026-11-03 (6 days ago)
Work arrangement	On-site at the location listed
Pay	Not published in the source listing

Job description

Labcorp is a global leader in laboratory services, providing the insights and answers that help healthcare providers, patients, researchers, pharmaceutical companies and health systems make confident decisions and improve outcomes. Through our unparalleled science, data, technology and laboratory network, we advance diagnostics, accelerate innovation and help address some of the world's most important health challenges. As we shape the future of healthcare, we are leveraging advanced technologies, intelligent digital solutions and data-driven innovation across our operations to enhance how work gets done and deliver greater value to customers and patients. With our global scale and deep expertise, you'll have the opportunity to do meaningful work, grow your career and make a real impact on people's health around the world. Together, we're improving health and improving lives.

Labcorp is seeking a Staff Software Engineer, Variant Classification to join our Labcorp Genetics team.

Work Schedule: This is a full-time, exempt (salaried) position assigned to a First Shift schedule, with standard business hours of Monday through Friday, 8:00 a.m. to 5:00 p.m. in your local time zone. Business needs may occasionally require flexibility in work hours, including earlier, later, or additional hours, with reasonable notice provided when possible.

Applicants who live within 35 miles of either the Burlington, NC or Durham, NC location will follow a hybrid schedule. This schedule includes a minimum of three in-office days per week at an assigned location, either Burlington or Durham, supporting both collaboration and flexibility.

Job Responsibilities:

Design and build tools that define, store, and provide meaningful variant, sample, and test level information to support accurate variant interpretation and report generation
Develop and maintain systems that translate raw bioinformatic data into variant and sample level information, including registration, normalization, observation groups, and quality metrics
Scale and optimize storage of sample level information to support growing data needs
Source, maintain, and provide annotations at the variant level necessary for accurate variant interpretation
Automate evidence placement and classification for variant interpretation
Support test content and assay development initiatives
Collaborate with data scientists, variant scientists, and software developers to design and implement solutions that meet stakeholder requirements

Minimum Qualifications:

Bachelor's degree with 10 or more years of recent professional software development experience
10 or more years of experience with Python (intermediate level or higher)
10 or more years of experience with relational databases and web development frameworks
10 or more years of experience with front-end technologies (e.g., React, Angular, Vue.js, JavaScript/TypeScript, HTML/CSS)
10 or more years of experience with RESTful APIs and microservices architecture
10 or more years of experience with CI/CD pipelines and DevOps practices
10 or more years of experience with cloud platforms (AWS, Azure, or GCP)

Preferred Qualifications:

Master's Degree or Ph.D. in Bioinformatics/Computational Biology or life sciences
8 or more years of experience mentoring and developing senior and junior engineers across multiple teams
8 or more years of experience defining technical vision and driving multi-year roadmaps
3 or more years of experience with bioinformatic tools and annotation
3 or more years of experience with variant databases and genomic data resources (e.g., ClinVar, gnomAD, HGMD)
3 or more years of experience in Spark, text mining, natural language processing, semantic enrichment, ontologies, data mining, or machine learning/AI
3 or more years of experience with public-domain biomedical terminologies (e.g., MeSH, NCIt, HGNC)
3 or more years of experience translating complex scientific questions into information solutions
Current or prior Labcorp experience

Additional Job Standards:

Owns and delivers product or platform goals across multiple years and teams, setting a high standard for technical outcomes and delivery
Defines the vision, scope, and technical approach for large, business-impacting projects with organization-wide implications
Identifies, prioritizes, and drives solutions to ambiguous, open-ended problems across multiple teams
Influences the roadmaps of partner teams to align with and achieve broader business goals
Serves as a role model and technical authority for engineers across multiple teams
Effective verbal and written communicator with both scientific and non-scientific audiences
Effective with GitHub Copilot, Claude Code or similar LLM tools to accelerate coding, testing and documentation

About Labcorp Genetics
Labcorp Genetics (formerly Invitae) is dedicated to bringing comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. The Variant Classification team builds and maintains the tools that define, store, and provide meaningful and detailed variant, sample, and test level information to support accurate variant interpretation and report generation. Our services support interpretation reporting of genetic variants and assay development across a suite of critical platforms including SDS, VDB, Argus, iVEP, Evidence Service, MoonPy, Cerebro, Universal Transcript Archive, SeqRepo, and Assay CMS.

At Labcorp we have a passion for helping people live happy and healthy lives. Every day we provide vital information that helps our clients and patients understand their health. If you are passionate about helping people and have a drive for service, then Labcorp could be a great next career step!

Application Window: 11/7/2026

Pay Range: $100K - $198K/yr

All job offers will be based on a candidate's skills and prior relevant experience, applicable degrees/certifications, as well as internal equity and market data.

LBP Only: The position is also eligible for an annual bonus under the Labcorp Bonus Plan. Bonuses are payable based on corporate and/or business segment performance and are subject to individual performance modifiers.

Benefits: Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical, Dental, Vision, Life, STD/LTD, 401(k), Paid Time Off (PTO) or Flexible Time Off (FTO), Tuition Reimbursement and Employee Stock Purchase Plan. Employees regularly scheduled to work less than 20 hours, Casual, Intern, and Temporary employees are only eligible to participate in the 401(k) Plan. Employees who are regularly scheduled to work a 7 on/7 off schedule are eligible to receive all the foregoing benefits except PTO or FTO. For more detailed information, please click here.

Labcorp is proud to be an Equal Opportunity Employer:

Labcorp strives for inclusion and belonging in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications and merit of the individual. Qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), family or parental status, marital, civil union or domestic partnership status, sexual orientation, gender identity, gender expression, personal appearance, age, veteran status, disability, genetic information, or any other legally protected characteristic. Additionally, all qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law.

We encourage all to apply

If you are an individual with a disability who needs assistance using our online tools to search and apply for jobs, or needs an accommodation, please visit our accessibility site or contact us at Labcorp Accessibility. For more information about how we collect and store your personal data, please see our Privacy Statement.

Explore around this job

Field: Technology Sub-niche: Software engineering All jobs at Labcorp Jobs in California Jobs in San Francisco, CA San Francisco city guide California state guide San Francisco County economy

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About the role

This is a Mid Level role in the Technology field (Software engineering) at Labcorp. Mid-level roles usually expect some years of relevant experience and the ability to work with limited supervision.

We could not match this job title to one occupation in the official wage statistics, so no pay estimate is shown. Pay is not in the source listing; ask the employer for the range and compare in the 240 job niches.

Does the pay work here? (estimate)

Gross salary a year Filing State income tax rate %

Estimate for a wage earner: 2026 federal brackets and standard deduction (IRS), Social Security 6.2% up to $184,500, Medicare 1.45% (+0.9% above $200,000 single / $250,000 married), and a state rate you set; set your own state tax rate. It ignores credits, pre-tax deductions, local taxes and benefits. Sources: IRS: tax year 2026 inflation adjustments · SSA wage base per Federal Register notice 2025-19763.

How to prepare and behave

This is editorial guidance, not information from the employer.

Read the whole description and match your examples to its requirements; use the same words the posting uses where they are true for you.
Research the employer before the interview: what it does, who its customers are and recent news; prepare two or three questions about the work.
Arrive early (or log in early for a video call), dress one step above the daily dress code, and test your camera and audio beforehand.
Answer with short stories: the situation, what you did and the result. Give numbers when you have them and never invent them.
Be honest about gaps; say what you did to learn and how fast you can close them.
Ask about the team, the first 90 days, how success is measured and the schedule; do not open with salary and time off.
When pay comes up, know the market range for the occupation and your lowest acceptable offer before you answer; ask for the full package in writing.
Send a short thank-you message within a day, mentioning one thing you discussed.
Have code, data work or projects you can show, and be ready to think aloud: many technical interviews test how you reason, not only the answer.

Know your rights as a candidate and an employee:

The city

The job is in San Francisco, CA. Below is what the official statistics say about living and working there.

How San Francisco compares. Among the 145 largest places in California, San Francisco is #4 by population, #139 for homeownership (#1 = highest), #20 for remote work (#1 = most), #25 for college degrees (#1 = most). Its county, San Francisco County, is #3 of 58 counties for average pay ($174,103).

The place in numbers

San Francisco has 830,235 residents (ACS 2020–2024), about 2.1% of the population of California. It covers 47 square miles of land, which works out to roughly 17,784 people per square mile. The median age is 40.0, 6% older than the state median (40.0 against 37.9).

Housing

The median gross rent is $2,476 a month (rent plus utilities), 22% above the state median ($2,476 against $2,036). Over a year that is 21.1% of the median household income. US housing guidance treats housing as affordable when it takes 30% of income or less, so the typical household is under that line. The median home value is $1,394,500, which is 9.9 times the median household income ($140,970); a ratio above 5 usually means buying is out of reach without savings or a second income. 38.2% of households own their home, 32% below the state average (38.2% against 55.9%). A low ownership share points to a rental-heavy market with more apartments and shorter stays.

Work and pay

The San Francisco-Oakland-Fremont, CA metropolitan area has 2,373,920 jobs in the BLS wage survey, and the median pay across all occupations is $74,260 a year, 46% above the national median ($74,260 against $50,980). The biggest occupation groups are office and administrative support (226,320 jobs, median $62,120); management (223,100 jobs, median $176,340); business and financial operations (207,030 jobs, median $112,960). The area is most specialised in computer and mathematical (1.9 times) and life, physical, and social science (1.8 times), where the share of workers is well above the national share. The best-paying groups with at least 5,000 jobs are management ($176,340) and computer and mathematical ($167,770). In 2026M09 the unemployment rate of San Francisco County was 4.0%. 69.6% of residents aged 16 and over are in the labour force. The city lies in San Francisco County; its jobs, pay by industry and GDP are on the county page.

Getting around

Among workers, 28.6% drive alone, 18.7% use public transit, 9.3% walk, 31.0% work from home. 21.6% of workers commute 45 minutes or more, 11% above the state average (21.6% against 19.4%). Remote work is more common than in the state as a whole, which widens the set of employers a resident can work for without moving.

People and education

60.3% of adults aged 25 and over hold a bachelor's degree or higher, 63% above the state share (60.3% against 37.1%). 34.0% of residents were born outside the United States, 26% above the state share (34.0% against 27.0%). The poverty rate is 11.2%, 7% below the state rate (11.2% against 12.0%).

Climate

The warmest month is Sep, averaging 59°F (14.9°C), and the coolest is Apr at 53°F (11.6°C). About 515 mm (20 inches) of precipitation falls in a year; Dec is the wettest month (112 mm) and Jul the driest (2 mm). These values come from NASA satellite-based climatology on a grid of about 50 km, so they describe the wider area, not a weather station in the city.

Nearby cities to compare

Closest cities in this guide: Daly City (31 miles, rent 3% higher); Pacifica (31 miles, rent 25% higher); San Bruno (34 miles, rent 12% higher); Millbrae (36 miles, rent 32% higher). Rent differences are against San Francisco; use the Compare tab to put any two cities side by side.

Full guide to San Francisco →California guide All jobs in San Francisco

Official links for San Francisco

These links go to official sources and open in a new window. The first one is the government's or company's own site as listed in Wikidata (property "official website"); check it before relying on it.

Where to live

CITY Official statistics Source: U.S. Census Bureau, American Community Survey 2020–2024 5-year (via Census Reporter) · Data: ACS 2020–2024

Places within 50 miles (straight line) of San Francisco, CA that have a guide, with what living there costs. No pay estimate is shown because the title did not match one occupation.

Sort:

Place ⇅	Distance from the job city ⇅	Median rent ⇅	Median home value ⇅	Median household income ⇅	Commute 45+ min ⇅	Rent as % of occupation pay ⇅	Open jobs there ⇅
San Francisco, CA	0 mi	$2,476	$1,394,500	$140,970	21.6%	n/a	Jobs
Daly City, CA	31 mi	$2,551	$1,115,000	$123,547	19.6%	n/a	—
Pacifica, CA	31 mi	$3,098	$1,249,800	$160,523	15.5%	n/a	—
San Bruno, CA	34 mi	$2,773	$1,207,500	$141,272	12.2%	n/a	—
Millbrae, CA	36 mi	$3,272	$1,934,900	$163,476	21.8%	n/a	—
Brisbane, CA	36 mi	$2,574	$1,232,200	$156,169	29.8%	n/a	—
South San Francisco, CA	36 mi	$2,802	$1,188,800	$136,578	15.2%	n/a	—
Half Moon Bay, CA	37 mi	$2,433	$1,549,500	$157,884	26.7%	n/a	—
Burlingame, CA	38 mi	$2,785	$2,000,001	$174,000	23.1%	n/a	—
Richmond, CA	40 mi	$1,960	$668,200	$95,391	28.8%	n/a	—
San Mateo, CA	41 mi	$3,077	$1,618,700	$153,504	15.8%	n/a	—
Berkeley, CA	41 mi	$2,133	$1,413,900	$108,092	20.8%	n/a	Jobs
Alameda, CA	42 mi	$2,474	$1,235,700	$137,697	27.3%	n/a	Jobs
Belmont, CA	43 mi	$2,875	$2,000,001	$205,297	18.6%	n/a	Jobs
Oakland, CA	44 mi	$1,979	$929,900	$101,600	21.9%	n/a	Jobs
Foster City, CA	44 mi	$3,501	$1,838,200	$199,143	20.6%	n/a	Jobs
San Carlos, CA	45 mi	$2,854	$2,000,001	$237,470	14.9%	n/a	—
Redwood City, CA	47 mi	$2,968	$1,801,700	$157,814	10.2%	n/a	Jobs
San Leandro, CA	48 mi	$2,186	$844,200	$101,420	23.7%	n/a	—
Atherton, CA	49 mi	$3,501	$2,000,001	$250,001	7.0%	n/a	—

Career paths

We could not match this title to one occupation, so here are the other sub-niches in Technology, where your skills may carry over:

Cybersecurity (366) Data, analytics and AI (1991) Cloud, IT and infrastructure (504) Product management (412)

Distances

CITY Calculation (straight line) Source: U.S. Census Bureau Gazetteer (coordinates) · Data: 2024

How far San Francisco, CA is from the 20 largest US cities, in straight-line miles (not driving distance). Click a column to sort.

Sort:

From ⇅	Straight-line distance (miles) ⇅	Population of that city ⇅
San Francisco, CA	0 mi	830,235
San Jose, CA	73 mi	990,138
Los Angeles, CA	364 mi	3,857,263
San Diego, CA	475 mi	1,389,526
Phoenix, AZ	678 mi	1,642,323
Seattle, WA	684 mi	754,195
Denver, CO	986 mi	718,877
Oklahoma City, OK	1,420 mi	697,125
Fort Worth, TX	1,484 mi	963,194
Dallas, TX	1,515 mi	1,307,930
San Antonio, TX	1,516 mi	1,479,835
Austin, TX	1,530 mi	979,539
Houston, TX	1,673 mi	2,328,253
Chicago, IL	1,885 mi	2,711,226
Indianapolis, IN	1,979 mi	885,860
Columbus, OH	2,142 mi	914,802
Charlotte, NC	2,332 mi	903,844
Jacksonville, FL	2,403 mi	977,670
Philadelphia, PA	2,550 mi	1,579,706
New York, NY	2,602 mi	8,483,844

Nearby cities with open jobs (within 120 miles)

Sort:

City ⇅	Straight-line distance ⇅	Open jobs ⇅
Alameda, CA	42 mi	15
Belmont, CA	43 mi	2
Redwood City, CA	47 mi	27
Palo Alto, CA	54 mi	24
Sunnyvale, CA	60 mi	12
Fremont, CA	62 mi	2
Pleasanton, CA	63 mi	1
Milpitas, CA	66 mi	2
Campbell, CA	67 mi	7
San Jose, CA	73 mi	661
Capitola, CA	79 mi	1
Sacramento, CA	103 mi	38

The employer

Labcorp is the employer in this listing. See all its open jobs here →

It is among the 200 largest US-headquartered employers in our list, with about 70,000 employees worldwide (2024). Company page with headquarters, state economy and official links →

Official links for Labcorp

What it is like to work at a company (culture, schedules, benefits) is not in the source data, so we do not describe it. Read the description and ask the questions under "How to prepare".

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FAQ

What is the Staff Software Engineer, Variant Classification job at Labcorp?

A mid level role in technology (software engineering) listed 6 days ago. The full description is on this page and on The Muse.

Where is this job?

San Francisco, CA.

How do I apply?

Use the "View this job and apply on The Muse" button. AtiveSite does not receive applications.

How much does it pay?

The listing does not publish pay, and we could not match the title to one official occupation.

What is the cost of living there?

Median rent in San Francisco is $2,476 a month and median household income $140,970 (ACS 2020–2024).

How old is this listing?

It was posted on 2026-11-03 (6 days ago). Jobs older than 90 days are not shown.

Are there similar jobs?

Yes: browse software engineering jobs in California.

Sources and terms

Job data: The Muse public API (listing dated 2026-11-03). The job disappears from this site when it disappears from the source.
Wages and projections: BLS OEWS (May 2025) and Employment Projections 2025–35.
City and county figures: Census Bureau ACS 2020–2024, BEA, BLS QCEW and LAUS, NASA POWER climatology; distances from Census Gazetteer coordinates.

AtiveSite is not affiliated with or endorsed by The Muse, the employer or any government agency, and does not process applications. Verify every detail with the employer before acting.

Sources

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